Articles

Phagocytic activity in the trabecular meshwork

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Abstract:

Trabecular meshwork (TM) cells are specialized cells with phagocytic function contained in the TM outflow pathway, a tissue responsible for draining aqueous humor out of the eye. Phagocytic activity in TM cells is thought to play an important role in outflow pathway physiology. Moreover, impaired phagocytic capacity has been associated to development and progression of several types of glaucoma. Despite its importance, the molecular mechanisms triggered by phagocytosis in TM cells and its regulation are still poorly understood. Here, the current literature of how phagocytic activity in the TM modulates outflow function is reviewed and discussed. Special emphasis has been put on identifying and highlighting the known concepts and the areas in which more research effort is needed.

Glaucoma Research 2018-2020, pp. 35-47 #3
Edited by: John R. Samples and Paul A. Knepper
© Kugler Publications, Amsterdam, The Netherlands

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