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Optical coherence tomography angiography in glaucoma

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Abstract:

Optical coherence tomography angiography (OCTA) uses flowing blood cells as intrinsic motion contrast to non-invasively image blood flow, providing 3D and quantifiable blood flow information. OCTA measurement has demonstrated decreased blood flow in glaucomatous eyes in the optic nerve head, peripapillary retina, and macula. Compared to structural OCT, OCTA has comparable diagnostic power and better correlation with visual field (VF). OCTA parameters correlate well with VF parameters in more advanced stages of glaucoma, exhibiting less floor effect compared to structural OCT. Due to the good correlation with VF, OCTA measurements could be used to simulate VF for the purpose of improving the objective staging and monitoring of glaucoma. To transform OCTA from a novel research tool to a powerful clinical diagnostic tool, large-scale longitudinal studies are needed to validate its application value in glaucoma diagnosis, staging, and monitoring.

Glaucoma Research 2020-2022, pp. 113-122 #11
Edited by: Paul A. Knepper and John R. Samples
© Kugler Publications, Amsterdam, The Netherlands

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